jpHMM: recombination analysis in viruses with circular genomes such as the hepatitis B virus

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jpHMM: recombination analysis in viruses with circular genomes such as the hepatitis B virus

jpHMM is a very accurate and widely used tool for recombination detection in genomic sequences of HIV-1. Here, we present an extension of jpHMM to analyze recombinations in viruses with circular genomes such as the hepatitis B virus (HBV). Sequence analysis of circular genomes is usually performed on linearized sequences using linear models. Since linear models are unable to model dependencies ...

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Improvement of the jpHMM approach to recombination detection in viral genomes and its application to HIV and HBV

Accurate virus genotyping and the detection of recombinant strains are of crucial importance for understanding viral evolution as well as the design of potential vaccines and treatment strategies. A very accurate tool for detecting recombinations in genomic HIV-1 sequences is jpHMM (jumping profile Hidden Markov Model). For a given sequence, it predicts recombination breakpoints and assigns a p...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 2012

ISSN: 0305-1048,1362-4962

DOI: 10.1093/nar/gks414